HUAIER RELIEVES OXALIPLATIN-INDUCED HEPATOTOXICITY THROUGH ACTIVATION OF THE PI3K/AKT/NRF2 SIGNALING PATHWAY IN C57BL/6 MICE

Huaier relieves oxaliplatin-induced hepatotoxicity through activation of the PI3K/AKT/Nrf2 signaling pathway in C57BL/6 mice

Hepatotoxicity caused by the anticancer medication oxaliplatin (OXA) significantly restricts its clinical use and raises the risk of liver damage.Huaier, a fungus Ski de fond - Homme - Skis - Back country found in China, has been demonstrated to have various beneficial effects in adjuvant therapy for cancer.However, the preventive impact of Huaier

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Glaucoma and Psychotropics

Introduction Glaucoma is a heterogeneous group of conditions which result in optic neuropathy and visual defects, majorly linked with the increase of intra-ocular pressure (IOP).It is known that psychotropic drugs have been implicated in drug induced angle-closure glaucoma, mostly through its anti-cholinergic effect.Objectives Systematize the drugs

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Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

Summary: Spliceosome machinery mutations are common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking.In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified RKI-1447, a Rho-associated protein kinase inhibitor, as select

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